One drug that contains THC is Sativex, which treats muscle spasms and stiffness from multiple sclerosis. In medicine, THC is often prescribed in tandem with CBD for a variety of conditions. In regions where cannabis is legal for recreational and/or medical use, you can buy THC isolate - that's the THC chemical by itself - to get the effects of the cannabinoid without any potential interference from the myriad other chemicals in weed. How is THC used in medicine or recreation?.It is the compound that causes all the stereotypical hallmarks of being stoned - including giggling, bumbling, silly "highdeas," and heightened appetite. THC is the chemical most commonly associated with smoking, vaping, or ingesting cannabis. The length of a cannabinoid's side chain determines its potency, at least in part, research shows. At the same time, it stimulates your reward system to release more of the neurotransmitter dopamine, which all adds up to the feeling of being “high.” When you take THC, it limits the brain’s capacity to learn new things and do complex tasks. One of the most important brain areas THC alters is the hippocampus, which plays a critical role in learning and memory. Anandamide and other endogenous cannabinoids affect the brain areas that play a role in pleasure, memory, cognition, concentration, movement, coordination, sensory perception, and perception of time, according to the National Institute on Drug Abuse. In the brain, THC mimics something known as the “ bliss molecule,” or anandamide, a chemical that naturally occurs in the body. Tetrahydrocannabinol (THC) mainly targets the CB1 receptors, which means the chemical affects the brain. TetrahydrocannabinolĬannabinoids bind to two receptors in the brain, CB1 and CB2 - CB1 is linked to the nervous system, while CB2 is connected to the immune system.
We focused on five cannabinoids - they’re the big ones to watch as cannabis’ wide-ranging potential therapeutic uses become increasingly important in modern medicine. Inverse spoke to the experts to find out exactly what scientists do - and don't - know about the different cannabinoids and what they do to our brains. "All cannabinoids are equally important." And some can have some unusual - and maybe even beneficial - effects. But from what little research has snuck through the barriers, we do know that the body’s own natural endocannabinoid responds uniquely to phytocannabinoids - those that come from the cannabis plant. Legal restrictions in cannabis - it is a Schedule 1 drug in the United States - mean researchers are stymied by protocol and lack of available resources to do the work. In a December 2019 study, scientists announced the discovery of two new cannabinoids - and both of them could pack some real psychoactive power, even compared to the well-known THC.īut despite how abundant they are and the affects they can have, most of the cannabinoids know to science remain a mystery: Scientists aren’t sure how exactly they change the brain and body. What is perhaps most exciting about these myriad chemicals are the potential therapeutic effects they could have - if the research holds up, cannabinoids could represent hundreds of new drugs for human benefit. In total, there are more than 500 cannabinoids, all of which can have an affect on our bodies and brains. In fact, scientists have discovered more than 100 other cannabinoids - and those are just the ones found in the cannabis plant. But while they are the most famous, they are far from the only cannabinoids.
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Both cannabidiol and tetrahydrocannabinol, to give them their full names, are cannabinoids - chemical compounds found in marijuana. When we think cannabis, most of us think of the chemical THC - although CBD is quickly rising in popularity, too.
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